A good-hitting catcher with a foul temperment, Meluskey came up as a rookie with the Astros in 1998. His career year was 2000 when he started and hit .300 with 14 homers and 69 RBIs.

Meluskey got into some conflicts with teammates and was traded to Detroit in a deal that brought Brad Ausmus back to Houston. Meluskey played eight games with the Tigers but was back in Houston the following season. He played 12 more games with the Astros before his release.

His final stats were a .283 average, 15 homers and 75 RBIs in 155 games.