Describing himself as "one tough Dominican", Andujar's pitching would prove as volatile and erratic as his fiery temper. His "You never know" would become almost as cliched as Craig Biggio's "That's just baseball".

After this right-handed starter arrived in Houston in 1975, he would be named to the All-Star game twice (1977, 1979), despite having only one winning season (11-8, 1977). As with most Astros, he seemed to blossom after leaving Houston. Andujar was traded to St. Louis in 1981 for Tony Scott, and had two 20-win seasons (1984-20, 1985-21) there. But true to form, he came unglued in Game 7 of the 1985 World Series against the Royals, arguing ball calls with the plate umpire which got him ejected from the game, then suspended.

Demanding to be traded, he spent 1986-87 in Oakland, then ended his career back in Houston in 1988 (2-5, 4.00 ERA). He attempted a comeback in 1989 in the short-lived Senior League (5 games, 1.31 ERA).